Algunas publicaciones

En esta sección encontrarás nuestras últimas publicaciones científicas. Estas investigaciones reflejan nuestro compromiso con la excelencia en el campo de la biotecnología y la bioinformática.

• Alvarez, G., Di Lella, S., Pickholz, M., Scodeller P, and Asciutto E.K. Deglycosylation induces a novel distal conformation in the mannose receptor CD206. Sci Rep 16, 5239 (2026). https://doi.org/10.1038/s41598-026-35240-y
• Lepland, A; Peranzoni, E.; Haljasorg, U.; Asciutto, E. K.; Crespíamer, M.; Modesti, L; Kilk, K; Lombardia, M; Acosta, G; Royo, M; Peterson, P; Marigo, I; Teesalu, T; Scodeller, Pablo, Peptide‐Drug Conjugate for Therapeutic Reprogramming of Tumor‐Associated Macrophages in Breast Cancer, Advanced Science; (2025)
• Arias, A.; Tovar-Martinez, L; Asciutto, E. K.; Mann, A; Põnograjeva, K; Gracia, L S; Royo, M; Haugas, M; Teesalu, T; Smulski, C; Ruoslahti, E; Scodeller, P A Cyclic Peptide Targets Glioblastoma by Binding to Aberrantly Exposed SNAP25, MOLECULAR PHARMACEUTICS; Washington; (2024).
• Trujillo, P; Garavaglia, P; Alvarez, G; Aduviri, S; Domene, C; Cannata, J; Asciutto, E K.; García, G. A.; Pickholz, M. Insight from atomistic molecular dynamics simulations into the supramolecular assembly of the aldo-keto reductase from Trypanosoma cruzi, Journal of Molecular Modeling, Berlin; (2024) vol. 30.
• F. Ormeño, I.J. General. Convergence and equilibrium in molecular dynamics simulations. Comm. Chem., 2024, 7, 2399-3669. https://doi.org/10.1038/s42004-024-01114-5
• M.L. Perez Saura, C.L. Cajachagua, A. Balan, I.J. General. Phosphate uptake in PhoX: Molecular mechanisms, Int. J. Biol. Macromol., 2024, 269, 131993. https://doi.org/10.1016/j.ijbiomac.2024.131993
• F. Pullara, M.C. Forsmann, I.J. General, J. C. Ayoob, E. Furbee, S. L. Castro, X. Hu, J.T. Greenamyre, R. Di Maio, NADPH oxidase 2 activity disrupts Calmodulin/CaMKIIα complex via redox modifications of CaMKIIα-contained Cys30 and Cys289: Implications in Parkinson’s disease. Redox Biol., 2024, 75, 103254. https://doi.org/10.1016/j.redox.2024.103254
• -R.C.N. Quiroz, E.A. Philot, I.J. General, D. Perahia, A.L. Scott. Effect of phosphorylation on the structural dynamics, thermal stability of human dopamine transporter: A simulation study using normal modes, molecular dynamics and Markov State Model, J. Mol. Graph, 2023, 118, 108359, doi. https://doi.org/10.1016/j.jmgm.2022.108359
• -G. Alvarez, T. Le, N. Wong, J. Echave, T. Pochapsky, and E. Asciutto, Hydroxylation Regiochemistry is Robust to Active Site Mutations in Cytochrome P450cam (CYP101A1), Biochemistry, (2022), 17, (61), p:1790-1800.
• A. Lepland, A. Malfanti, U. Haljasorg, E. Asciutto, M. Pickholz, M. Bringas, S. Dordevic, L. Salumae, P. Peterson, T. Teesalu, M. Vicent and P. Scodeller, Depletion of Mannose Receptor Positive Tumor Associated Macrophages via a Peptide Targeted Star-Shaped Polyglutamate inhibits Breast Cancer Progression in Mice, Cancer Research Comm., (2022).
• Prakash Lingasamy, Kristina Põšnograjeva, Sergei Kopanchuk, Allan Tobi, Ago Rinken, Ignacio J General, Eliana K Asciutto, Tambet Teesalu, PL1 peptide engages acidic surfaces on tumor-associated fibronectin and tenascin isoforms to trigger cellular uptake, Pharmaceutics 13 (12), 1998, (2021)
• 8-EK Asciutto, S Pantano, IJ General, Physical interactions driving the activation/inhibition of calcium/calmodulin dependent protein kinase II, Journal of Molecular Graphics and Modelling 105, 107875, (2021)
• Ana Gonzalez Wusener, Angela Gonzalez, Maria E. Perez Collado, Melina R. Maza, Ignacio J. General, Carlos O. Arregui, Protein Tyrosine Phosphatase 1B, PTP1B, Targets Fak and Paxillin in Cell-Matrix Adhesions. J. Cell Sci., 2021, doi. https://doi.org/10.1242/jcs.258769
• Eliana K. Asciutto, Sergio Pantano, Ignacio J. General. Physical Interactions Driving the Activation/Inhibition of Calcium/Calmodulin Dependent Protein Kinase II, J. Mol. Graph, 2021, 105, doi https://doi.org/10.1016/j.jmgm.2021.107875
• A Lepland, EK Asciutto, A Malfanti, L Simón-Gracia, V Sidorenko, Maria J Vicent, Tambet Teesalu, Pablo Scodeller, Targeting pro-tumoral macrophages in early primary and metastatic breast tumors with the CD206-binding mUNO peptide, Molecular pharmaceutics 17 (7), 2518-2531, (2020).
• P Scodeller, EK Asciutto, Targeting tumors using peptides, Molecules 25 (4), 808, (2020).